Notts bowler Stuart Broad was England’s standout performer in a second consecutive defeat to India in Indore.
Broad finished with figures of 4-55 having reduced India to 29-3 before Yuvraj Singh devastated the tourist with a classy 118.
"We came with the intention of getting early wickets and we were delighted to get three in the first 10 overs,” said Broad.
"Sometimes you have to put credit on the opposition and they batted fantastically through that middle period on what was a very quick-scoring ground.
"There are still five games left, it's a long time - we know how momentum can change and cricket and if we win the next one we can go on a little run so that's certainly our aim.”
A quick 43 from Andrew Flintoff and a composed 58 from Owais Shah were the other high points for England.
Samit Patel conceded 37 runs from his five overs and hit a six and a four on his way to 20 from 25 balls.
England will now travel to Kanpur to prepare for match three of the series on Thursday.
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