Fraser Sheat led a battling Nottinghamshire display with the ball as Hampshire, in spite of Jake Lehmann’s century, reached stumps on day two at 267-7, still over 100 runs adrift.
Lehmann made a patient unbeaten 115, but Sheat’s return of 3/61 from 19 overs, backed up by Olly Stone’s 2/58, helped the hosts keep hold of the driving seat at the halfway point at Trent Bridge.
Tom Giles and Dillon Pennington also collected a scalp each as Notts, on a slow-moving day, allowed the visitors to score only 263 runs all day, with their average scoring rate a miserly 2.74 per over.
Stone struck with the very first ball of the day, having Felix Organ caught behind by debutant Mitchell Hay for six as the hosts aimed to back up a fine opening day with the bat that saw them total 377.
Despite the 61-run second-wicket stand between Nick Gubbins and Toby Albert that followed, Notts continued to probe away, and found their rewards when both fell in the space of four balls before lunch.
Albert was first to go, lbw to 20-year-old Academy graduate seamer Tom Giles for 31, before the same manner of dismissal, this time at the hands of Dillon Pennington, befell opener Gubbins for 35.
Lehmann resolutely added 41 alongside Joe Weatherley to see the Rose and Crown through to the break without any further damage, but it was only nine overs after the resumption when Stone struck again.
With Weatherley opting to shoulder arms and therefore bringing the option of impact outside off into play, Stone pinned him lbw for 25 as his eventual 68-run alliance with Lehmann was ended.
The left-hander found brief support from Ben Brown, only for Sheat to claim his first scalp of the day to remove the Hampshire captain, caught by Patterson-White at first slip off a mistimed cut for 14.
Lehmann did move to an 88-ball fifty not long afterwards, but when talented youngster Ben Mayes was caught behind by Hay to give Sheat another wicket, it was part of a sticky passage of play for the visitors.
Only 50 runs came from the 30 overs prior to the tea break, which arrived with Hampshire 190-6, still in danger of following on, even as Lehmann remained resolute on 72.
However, a testing partnership between the 34-year-old, who went on to post three figures in 160 balls, and Scott Currie, nudged Hampshire past that danger as 97 was put on for the seventh wicket.
By the time they were parted, via a beautiful nip-backer from Sheat to bowl Currie for 35 - his runs having been made during a 143-ball vigil - the visitors were 262-7, trailing by 115.
Eddie Jack then helped Lehmann survive through to the close, adding five more runs from the 31 closing deliveries, but Nottinghamshire retain more than an air of positivity as their lead still numbers 110.