Jos Buttler’s explosive 52-ball 116 not out guided England to a 3-1 series victory in the UAE as Pakistan struggled to 271 all out in reply to the visitors' 355-5.
The imposing total was England’s highest ever away from home as Buttler smashed eight sixes, the most by an Englishman in an ODI innings.
The Lancashire wicketkeeper’s heroics came off the back of Jason Roy’s maiden century and a run-a-ball 71 from Joe Root.
The spin duo of Moeen Ali and Adil Rashid then shared six wickets - and Alex Hales took two spectacular catches - as the tourists emerged victorious by 84 runs.
At the start of the day, Eoin Morgan won the toss and chose to bat as England named an unchanged side for a fourth match in a row for only the second time ever in ODI cricket.
Roy and Hales made a tentative start in tough early conditions, adding 54 inside the first 11 overs, before Pakistan made their first breakthrough.
Mohammad Irfan found some extra bounce to trouble Hales and the opener top-edged into the hands of Shoaib Malik on 22.
Root joined Roy and the pair set about laying the platform for the late Buttler onslaught.
Roy edged towards his first ODI century and, despite being dropped on 77 by Mohammad Rizwan in the slips, he reached the landmark off 113 balls with a single off Shah.
Root fell soon afterwards, missing a reverse sweep off Azhar Ali to be stumped on 71, giving the Pakistan captain his first ODI wicket.
Moments later, England captain Eoin Morgan suffered the exact same fate having added 14.
Buttler, seemingly unaffected by the loss of three quick wickets for 33, proceeded to smash the Pakistan attack to all parts of the Dubai International Cricket Stadium.
Promoted to number four in the order, the 25-year-old broke records aplenty and enjoyed intelligent support from James Taylor who contributed 13 to a fifth wicket partnership of 79.
Buttler’s 46-ball century was the fastest by an Englishman, beating his 61-ball effort against New Zealand this summer, as he also became the first player to score 100 runs in the final ten overs of an ODI.
His 116 not out included eight fours and eight sixes as England posted their highest ever ODI total away from home.
Ali and Shehzad stepped out in pursuit of the biggest ODO chase ever in the UAE and made a purposeful start by putting on 45 in 6.3 overs before David Willey struck.
The left-armer utilised the short ball effectively and Shehzad was unable to keep a pull shot down as Moeen Ali caught him in the deep for 13.
Willey then removed the Pakistan captain in his next over, caught and bowled for 44, Pakistan losing their second wicket with 64 on the board.
The tourists were determined to stay in touch with the required seven-an-over run-rate - and cameo contributions from Mohammad Hafeez (37 off 36), Babar Azam (51 off 51), Shoaib Malik (52 off 34), Sarfraz Ahmed (24 off 26) and Anwar Ali (24 of 24) ensured that they did just that.
Wickets were, however, tumbling at regular intervals and - with Hales making up for an earlier drop by taking a pair of diving catches to dismiss each of the two half-centurions -England closed in on their series clinching victory.
The winning moment arrived in the 41st over when Chris Woakes took a low catch at short cover to dismiss Anwar off Moeen Ali.
It had been a morale boosting performance from England’s two spinners, as it was for opener Jason Roy.
The day, however, belonged to Buttler.
England are returning to the scene of their Ashes triumph in 2016 for Royal London One-Day Internationals against Sri Lanka and Pakistan.
Don't miss the opportunity to watch some of the best players in the world go toe-to-toe in the unique surroundings of Trent Bridge and secure your seats now.